Alzheimer's Dis. and Memory Drugs

GENERICAUSUSUK Class
donepezil
M R 		AriceptAriceptAriceptcholinesterase inhibitor
gingko biloba
gingko biloba gingko biloba gingko bilobasmart herb (?)
nimodipine ¹
S 		NimotopNimotopNimotopCalcium Channel Blocker
piracetam
S 		-o Nootropilnootropic
rivastigmine Exeloncholinergic
selegiline ²
R 		EldeprilDeprenyl; EldeprylEldepryl; Vivapryl; Stilline; CentraprylMAO-B inhibitor; decreases free radicals
tacrine
Cognex, THAoocholinesterase inhibitor

NOTES
¹ -- Used clinically for heart disease. Experimental in Alz. Dis.
² -- Clinical use in Parkinson's Dis. Experimental in Alz. Dis.

Experimental Drugs for Alzheimer's Dis.

GENERICPhase of researchCountry Class
aniracetam IIInootropic
ascorbic acid
(Vit C) 		Experimentalantioxidant
eptastigmine II / III Italy / USA cholinesterase inhibitor
desferrioxamine Experimentalchelates aluminium
galanthamine Preregistration Europe / USA cholinesterase inhibitor
huperzine A III Preclinical China / USAcholinesterase inhibitor
metrifonate II / III US / Germanycholinesterase inhibitor
NSAIDs Experimental
physostigmine retard Preregistration Europe / USAcholinesterase inhibitor
retinol (Vit A) Experimentalantioxidant
SDZ-ENA-713 II / III Japan / US / Europecholinesterase inhibitor
siagoside II / IIIganglioside
selegiline Experimentaldecreases free radicals
tocopherol (Vit E) Experimentalantioxidant

Table prepared from info in:
Parnetti, L, et al. "Cognitive Enhancement Therapy for Alzheimer's Disease: The Way Forward" in Drugs (ADIS International) May 1997 53:5 (751-764)

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