Alzheimer's Dis. and Memory Drugs

GENERIC AUS US UK Class
donepezil
M R 		Aricept Aricept Aricept cholinesterase inhibitor
gingko biloba
gingko biloba gingko biloba gingko biloba smart herb (?)
nimodipine ¹
 Nimotop Nimotop Nimotop Calcium Channel Blocker
piracetam
 - o Nootropil nootropic
rivastigmine Exelon cholinergic
selegiline ²
R 		Eldepril Deprenyl; Eldepryl Eldepryl; Vivapryl; Stilline; Centrapryl MAO-B inhibitor; decreases free radicals
tacrine
 Cognex, THA o o cholinesterase inhibitor

NOTES
¹ -- Used clinically for heart disease. Experimental in Alz. Dis.
² -- Clinical use in Parkinson's Dis. Experimental in Alz. Dis.

Experimental Drugs for Alzheimer's Dis.

GENERIC Phase of research Country Class
aniracetam III nootropic
ascorbic acid
(Vit C) 		Experimental antioxidant
eptastigmine II / III Italy / USA cholinesterase inhibitor
desferrioxamine Experimental chelates aluminium
galanthamine Preregistration Europe / USA cholinesterase inhibitor
huperzine A III Preclinical China / USA cholinesterase inhibitor
metrifonate II / III US / Germany cholinesterase inhibitor
NSAIDs Experimental
physostigmine retard Preregistration Europe / USA cholinesterase inhibitor
retinol (Vit A) Experimental antioxidant
SDZ-ENA-713 II / III Japan / US / Europe cholinesterase inhibitor
siagoside II / III ganglioside
selegiline Experimental decreases free radicals
tocopherol (Vit E) Experimental antioxidant

Table prepared from info in:
Parnetti, L, et al. "Cognitive Enhancement Therapy for Alzheimer's Disease: The Way Forward" in Drugs (ADIS International) May 1997 53:5 (751-764)

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