Anti-Migraine, Cluster, and Tension HA Drugs:
b) Preventatives
b) Preventatives
| GENERIC | AUS | US | UK | Canada, Sth Africa, etc. | Class |
|---|---|---|---|---|---|
| amitriptyline M | Tryptanol; Elavil; Endep; Amitrol | Elavil; Endep; Emitrip | Trytizol; Lentizol | Levate: Novotriptyn (Can) | tricyclic antidepressant |
| atenolol R | Tenormin; Noten; Tenlol; Tensig | Tenormin | Tenormin; | Aterol (SA) | beta-blocker |
| clonidine R | Catapres; Dixarit | Catapres | Dixarit; Catapres | Menograine (SA) | alpha adrenoceptor agonist |
| cyproheptadine | ¶ Periactin | Periactin; Cyprohept | ¶ Periactin | antihistamine | |
| diltiazem | Cardizem CD; Diltahexal; Dilzem | Cardizem | Adizem-60; Slozem; Calcicard CR: Angitil SR; Viazem XL | Ca++ channel blocker | |
| divalproex sodium (SR) | [see valproic acid] | anticonvulsant | |||
| dothiepin | Prothiaden; Dothep | - | Prothiaden | dosulepin; Thaden; Jardin (SA) | tricyclic |
| doxepin M | Sinequan; Deptran | Adapin; Sinequan | Sinequan | tricyclic antidepressant | |
| Feverfew | ¶ Feverfew | ¶ Feverfew | ¶ Feverfew | Herb - ?5HT antagonist | |
| fenoprofen M | Fenopron | Nalfon | Fenopron | NSAID | |
| flunarizine | Ca++ Channel Blocker | ||||
| gabapentin R M | Neurontin | Neurontin | Neurontin | anticonvulsant | |
| hydroxyzine M | ¶ Atarax | Atarax; Vistaril; Anxanil | Atarax | antihistamine | |
| ibuprofen M | ¶ Nurofen; ¶Actiprofen; ¶ ACT-3; Brufen; Rafen; | ¶ Advil; ¶ Motrin; Haltran; Trendar | ¶ Advil; ¶ Nurofen; Cuprofen; Brufen; Apsifen; Ebufac; Fenbid; others | NSAID | |
| imipramine H R | Tofranil | Janimine; Norfranil; Tofranil; Tipramine | Tofranil | Impril; Novapramine (Can); Ethipramine; Panpramine; Miprilin (SA) | tricyclic |
| indobuprofen | - | - | Flosint | NSAID | |
| ketoprofen R M | Orudis; Oruvail | Orudis; Oruvail | Orudis; Oruvail; Alrheumat | Rhodis(Can) | NSAID |
| lithium carbonate M | Lithicarb | Eskalith; Lithonate; Lithotabs; Lithobid; Cibalith | Camcolit; Liskonum; Priadel | Carbolith; Duralith(Can) | mood stabiliser |
| lithium citrate | - | - | Litarex; Li-Liquid | mood stabiliser | |
| methdilazine | Dilosyn | Tacaryl | - | antihistamine | |
| methysergide | Deseril | Sansert | Deseril | 5HT rec. antag. | |
| metoprolol R M | Betaloc; Lopresor; Minax | Lopressor | Betaloc, Lopresor | beta-blocker | |
| nadolol M | - | Corgard | Corgard | beta-blocker | |
| naproxen sodium | ¶ Naprogesic | ¶ Aleve; Anaprox; Aflexan | Synflex | Synflex | NSAID |
| naproxyn M A | Naprosyn; Anaprox; Inza; Proxen; Synflex; | Naprosyn; EC Naprosyn | Naprosyn; Synflex; Napratec; Nycopren | NSAID | |
| nifedipine M | Adalat; Adapine; Nyefax | Adalat: Procardia | Adalat; Coracten; Nifensar; Hypolar; Cardilate | Ca++ Channel Blocker | |
| nimodipine | Nimotop | Nimotop | Nimotop | Ca++ Channel Blocker | |
| nortriptyline M | Allegron | Aventyl; Pamelor | Allegron | tricyclic anti-depressant | |
| phenelzine | Nardil | Nardil | Nardil | MAOI | |
| pizotifen | Sandomigran | Sandomigran; Pizotyline | Sanomigran | 5HT rec. antag. | |
| propranolol R M | Inderal; Deralin | Inderal LA; Inderide LA | Inderal | Detensol; Novopranol; (Can): Nolol; Prodorol(SA) | beta-blocker |
| protriptyline | - | Vivactil | Concordin | tricyclic antidepressant | |
| sodium valproate | Epilim; Valpro | - | Epilim | anticonvulsant | |
| timolol M | Blocadren | Blocadren | Blocadren; Betim | beta-blocker | |
| tolfenamic acid | NSAID | ||||
| valproic acid = divalproex R | Depakote; Depakene; Myproic Acid; Dalpro | Convulex | Depakene; Epival(Can) | anticonvulsant | |
| verapamil M | Isoptin; Veracaps; Cordilox; Anpec | Calan; Veralan; Isoptin; Covera-HS | Cordilox; Securon; Univer | Ca++ Channel Blocker | |
Notes
Not all possible preventative agents are listed here. Especially see the following pagesfor further drugs in the classes mentioned here:
3a Antidepressants ; NSAIDs ; Calcium Channel Blockers ; Beta Blockers
However the most popular agents from these classes for the prevention of migraine
are listed above.
SR = Sustained Release.
¶ = Available without prescription, OTC.
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